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Targeting alternative splicing in cancer immunotherapy

10 Aug 2023

Abstract excerpt

Tumor immunotherapy has made great progress in cancer treatment but still faces several challenges, such as a limited number of targetable antigens and varying responses among patients. Alternative splicing (AS) is an essential process for the maturation of nearly all mammalian mRNAs. Recent studies show that AS contributes to expanding cancer-specific antigens and modulating immunogenicity, making it a promising...

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PMID: 37635865
DOI: 10.3389/fcell.2023.1232146

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