Article

Bacterial Infection Remodels the DNA Methylation Landscape of Human Dendritic Cells

2015-03-04

Abstract excerpt

DNA methylation is thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendritic cells (DCs) with a pathogenic bacteria is associated with rapid changes in methylation at thousands of loci. Infection-induced changes in methylation occur primarily at distal enhancer elements, including those associated with the activati...

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Identifiers and source

Literature Corpus work: 06cd098a-8694-5244-b7f6-541771ab0d2e
DOI: 10.1101/016022

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