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Gene activation precedes DNA demethylation in response to infection in human dendritic cells

18 Mar 2019

Abstract excerpt

DNA methylation is considered to be a relatively stable epigenetic mark. However, a growing body of evidence indicates that DNA methylation levels can change rapidly; for example, in innate immune cells facing an infectious agent. Nevertheless, the causal relationship between changes in DNA methylation and gene expression during infection remains to be elucidated. Here, we generated time-course data on DNA...

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PMID: 30886108
DOI: 10.1073/pnas.1814700116

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