Article
Methylation in Mycobacterium tuberculosis is lineage specific with associated mutations present globally.
Scientific reports - 9 Jan 2018
Phelan Jody, de Sessions Paola Florez, Tientcheu Leopold, Perdigao Joao, Machado Diana, Hasan Rumina, Hasan Zahra, Bergval Indra L, Anthony Richard, McNerney Ruth, Antonio Martin, Portugal Isabel, Viveiros Miguel, Campino Susana, Hibberd Martin L, Clark Taane G
Abstract excerpt
DNA methylation is an epigenetic modification of the genome involved in regulating crucial cellular processes, including transcription and chromosome stability. Advances in PacBio sequencing technologies can be used to robustly reveal methylation sites. The methylome of the Mycobacterium tuberculosis complex is poorly understood but may be involved in virulence, hypoxic survival and the emergence of drug...
Topics
- Computational Biology
- DNA Methylation
- Genome, Bacterial
- Humans
- Methyltransferases
- Mutation
- Mycobacterium tuberculosis
- Nucleotide Motifs
- Phylogeny
- Tuberculosis