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Article

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

5 Sept 2019

Abstract excerpt

The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and discovered unique transcriptional profiles. The majority of genes differentially expressed between the clades encode proteins involved in host interaction and metabolic functions. A significant...

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PMID: 31488832
DOI: 10.1038/s41467-019-11948-6

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