Article

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids

2025-12-03

Abstract excerpt

Gene regulatory networks establish cell identity during development by regulating transcription factor binding at cis-regulatory elements, many of which require chromatin remodelers for accessibility. Although these key principles of gene regulation in mammalian development have emerged, the contribution of chromatin remodellers to early human embryogenesis remains unclear. Here, we show that the SWI/SNF ATPases S...

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Literature Corpus work: 5fa8bf7b-0bb3-571a-b4a4-94d68e3a3011
DOI: 10.64898/2025.12.01.691499

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