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Article

Tumor suppressor SMARCB1 suppresses super-enhancers to govern hESC lineage determination

29 Apr 2019

Abstract excerpt

The SWI/SNF complex is a critical regulator of pluripotency in human embryonic stem cells (hESCs), and individual subunits have varied and specific roles during development and in diseases. The core subunit SMARCB1 is required for early embryonic survival, and mutations can give rise to atypical teratoid/rhabdoid tumors (AT/RTs) in the pediatric central nervous system. We report that in contrast to other studied...

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PMID: 31033435
DOI: 10.7554/elife.45672

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