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Article

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

14 Aug 2020

Abstract excerpt

Alkb homolog 7 (ALKBH7) is a mitochondrial α-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis, but its function and substrates remain unclear. Herein, we show ALKBH7 regulates dialdehyde metabolism, which impacts the cardiac response to ischemia-reperfusion (IR) injury. Using a multi-omics approach, we find no evidence ALKBH7 functions as a prolyl-hydroxylase, but we do find Alkbh7 -/- mice...

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PMID: 32795389
DOI: 10.7554/elife.58573

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