Article

cGAS-STING dependent type I IFN protects against <i>Leptospira interrogans</i> renal colonization in mice

2025-06-04

Abstract excerpt

Leptospira interrogans is the major causative agent of leptospirosis. Humans, canines and livestock animals are susceptible to Leptospira species and can develop fulminant disease. Rodents serve as reservoir hosts in which the bacteria colonize the renal tubules and are excreted in the urine. The host immune response to Leptospira spp. remains poorly defined. We show that L. interrogans induces a robust type I...

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Literature Corpus work: 0691f125-87c4-54a0-b252-d429a4ea5f2d
DOI: 10.1101/2025.06.02.657349

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