Article

Role of TLR4 in persistent <i>Leptospira interrogans</i> infection: a comparative <i>in vivo</i> study in mice

2020-06-15

Abstract excerpt

Toll-Like Receptor (TLR) 4, the LPS receptor, plays a central role in the control of leptospirosis and absence of TLR4 results in lethal infection in mice. Because human TLR4 does not sense the atypical leptospiral-LPS, we hypothesized that TLR4/MD-2 humanized transgenic mice (huTLR4) may be more susceptible to leptospirosis than wild-type mice, and thus may constitute a model of acute human leptospirosis. Therefo...

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Literature Corpus work: 3ce5ec37-8a37-5147-9dc8-c8afb6169ff8
DOI: 10.1101/2020.06.15.153106

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