Article

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

2020-11-13

Abstract excerpt

<h4>Summary</h4> Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here, we aimed to model this transition to define underlying biological mechanisms and identify potential avenues for therapeutic intervention. Small cell lung cancer (SCLC) is neuroendocrine in origin and, in contrast to non-SCLC (NSCLC), rarely...

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Literature Corpus work: 0679bec3-8707-5ca2-9dba-47a36d5b5ae1
DOI: 10.1101/2020.11.12.368522

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