Article
Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation.
Cancer discovery - 1 Dec 2021
Quintanal-Villalonga Alvaro, Taniguchi Hirokazu, Zhan Yingqian A, Hasan Maysun M, Chavan Shweta S, Meng Fanli, Uddin Fathema, Manoj Parvathy, Donoghue Mark T A, Won Helen H, Chan Joseph M, Ciampricotti Metamia, Chow Andrew, Offin Michael, Chang Jason C, Ray-Kirton Jordana, Tischfield Sam E, Egger Jacklynn, Bhanot Umesh K, Linkov Irina, Asher Marina, Sinha Sonali, Silber Joachim, Iacobuzio-Donahue Christine A, Roehrl Michael H, Hollmann Travis J, Yu Helena A, Qiu Juan, de Stanchina Elisa, Baine Marina K, Rekhtman Natasha, Poirier John T, Loomis Brian, Koche Richard P, Rudin Charles M, Sen Triparna
Abstract excerpt
Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung cancer (SCLC) is a recognized resistance mechanism. Defining molecular mechanisms of neuroendocrine (NE) transformation in lung cancer has been limited by a paucity of pre/posttransformation clinical samples. Detailed genomic, epigenomic,...
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