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Transformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancer

2022-11-18

Abstract excerpt

<h4>Background: </h4> Histological transformation to small cell lung cancer (SCLC) has been identified as a mechanism of TKIs resistance in EGFR -mutant non-small cell lung cancer (NSCLC). However, the prevalence of transformation in EGFR -wildtype NSCLC and the mechanism are rarely understood. Methods We reviewed 1474 NSCLC patients to investigate the NSCLC-to-SCLC transformed cases and the basic clinical charac...

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Literature Corpus work
12a0cade-9458-524f-8357-0fe7bba54cae
DOI
10.21203/rs.3.rs-2278897/v1
Open publication

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Transformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancerDOI 10.21203/rs.3.rs-2278897/v1
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