Article
Identifying a missing lineage driver in a subset of lung neuroendocrine tumors.
Genes & development - 1 Jul 2018
Pozo Karine, Minna John D, Johnson Jane E
Abstract excerpt
Tumor heterogeneity of a primary histologic cancer type has major implications for cancer research and therapeutics. An important and understudied aspect of this heterogeneity is the role of transcription factors that serve as "lineage oncogenes" in a tumor type. A demonstration that different subgroups have distinct dependencies on lineage-specific transcription factors is highlighted in a relatively homogenous...
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