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Article

Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer.

Biochemical and biophysical research communications - 12 Nov 2023

Jing Meng, He Xia, Cai Cheng Zhi, Ma Qi Zhi, Li Kai, Zhang Ben Xia, Yin Yuan, Shi Ming Song, Wang Yong Sheng

Abstract excerpt

Epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) is clinically and genetically heterogeneous, with concurrent RB1/TP53 mutations, indicating an increased risk of transformation into small cell lung cancer (SCLC). When tumor cells convert into a different histological subtype, they lose their dependence on the original oncogenic driver, resulting in therapeutic resistance. However,...

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Identifiers

PMID: 37783120
DOI: 10.1016/j.bbrc.2023.09.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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