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Article

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer.

eLife - 14 Jun 2021

Inoue Yusuke, Nikolic Ana, Farnsworth Dylan, Shi Rocky, Johnson Fraser D, Liu Alvin, Ladanyi Marc, Somwar Romel, Gallo Marco, Lockwood William W

Abstract excerpt

Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here, we aimed to model this transition to define underlying biological mechanisms and identify potential avenues for therapeutic intervention. Small cell lung cancer (SCLC) is neuroendocrine in identity and, in contrast to non-SCLC (NSCLC), rarely contains...

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Identifiers

PMID: 34121659
DOI: 10.7554/eLife.66524
PMCID: PMC8337080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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