Article
Geographic Differences in the Contribution of ubiA Mutations to High-Level Ethambutol Resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Jul 2016
Lingaraju Subramanya, Rigouts Leen, Gupta Aditi, Lee Jongseok, Umubyeyi Alaine Nyaruhirira, Davidow Amy L, German Susan, Cho EunJin, Lee Ji-Im, Cho Sang-Nae, Kim Cheon Tae, Alland David, Safi Hassan
Abstract excerpt
Ethambutol (EMB) resistance can evolve through a multistep process, and mutations in the ubiA (Rv3806c) gene appear to be responsible for high-level EMB resistance in Mycobacterium tuberculosis We evaluated the prevalence of ubiA and embB (Rv3795) mutations in EMB-resistant strains originating from Africa and South Korea. No differences in embB mutation frequencies were observed between strains from both origins....
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