Back to search

Article

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer’s Disease

2024-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Enhancing protein O-GlcNAcylation by pharmacological inhibition of the enzyme O-GlcNAcase (OGA) is explored as a strategy to decrease tau and amyloid-beta phosphorylation, aggregation, and pathology in Alzheimer’s disease (AD). There is still more to be learned about the impact of enhancing global protein O-GlcNAcylation, which is important for understanding the mechanistic path of using OGA inh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0600c011-a72c-510b-b202-206170c0d4c4
DOI
10.1101/2024.09.19.613769
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer’s DiseaseDOI 10.1101/2024.09.19.613769
O -GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosisSemantic proximity
O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment.Semantic proximity
Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid modelSemantic proximity
Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s diseaseSemantic proximity
Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in <i> App <sup>NL-G-F</sup> </i> , <i> App <sup>NL-F</sup> </i> and 3xTg-AD mouse modelsSemantic proximity
Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s DiseaseSemantic proximity
Excessive <i>O</i> - GlcNAcylation causes heart failure and sudden deathSemantic proximity
Diazoxide/dibenozylmethane treatment mitigates spatial memory deficits and pathology and upregulates protective genes in an Alzheimer’s transgenic rat modelSemantic proximity
Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s DiseaseSemantic proximity
Simple gangliosides co-localize with amyloid plaques and increase with age in a transgenic mouse model of Alzheimer’s diseaseSemantic proximity
O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.Semantic proximity
<i>O</i> -GlcNAcylation effect on Tau in modulating its seeding and cellular transmission in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.