Article
O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment.
Neurobiology of aging - 1 Jan 2013
Kim Chaeyoung, Nam Dong Woo, Park Sang Yoon, Song Hyundong, Hong Hyun Seok, Boo Jung Hyun, Jung Eun Sun, Kim Yoonhee, Baek Ju Yuel, Kim Kwan Soo, Cho Jin Won, Mook-Jung Inhee
Abstract excerpt
Deposition of β-amyloid (Aβ) as senile plaques and disrupted glucose metabolism are two main characteristics of Alzheimer's disease (AD). It is unknown, however, how these two processes are related in AD. Here we examined the relationship between O-GlcNAcylation, which is a glucose level-dependent post-translational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to proteins, and Aβ production in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.