Article

<i>O</i> -GlcNAcylation effect on Tau in modulating its seeding and cellular transmission in Alzheimer’s Disease

2026-05-27

Abstract excerpt

Post-translational modifications critically regulate neurodegenerative disease progression. In Alzheimer’s disease (AD) and tauopathies, Tau hyperphosphorylation promotes aggregation and pathological spreading, whereas O- GlcNAcylation has emerged as a protective modification alongside its interplay with phosphorylation. However, the role of in vitro site-specific and global O - G lcNAcylation in Tau proteinopa...

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Literature Corpus work: 58fe34a8-bc08-551c-a3cc-6b73e6589b62
DOI: 10.64898/2026.05.27.728078

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