Article

Learning epistatic gene interactions from perturbation screens

2020-08-25

Abstract excerpt

<h4> A bstract </h4> The treatment of complex diseases often relies on combinatorial therapy, a strategy where drugs are used to target multiple genes simultaneously. Promising candidate genes for combinatorial perturbation often constitute epistatic genes, i.e., genes which contribute to a phenotype in a non-linear fashion. Experimental identification of the full landscape of genetic interactions by perturbing...

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Literature Corpus work: 05ce6cf5-d405-52cf-856d-1ed4317cfe5f
DOI: 10.1101/2020.08.24.264713

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