Gene network inference by probabilistic scoring of relationships from a factorized model of interactions.

Abstract excerpt

MOTIVATION: Epistasis analysis is an essential tool of classical genetics for inferring the order of function of genes in a common pathway. Typically, it considers single and double mutant phenotypes and for a pair of genes observes whether a change in the first gene masks the effects of the mutation in the second gene. Despite the recent emergence of biotechnology techniques that can provide gene interaction...

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