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Article

A fast lasso-based method for inferring higher-order interactions.

PLoS computational biology - 1 Dec 2022

Elmes Kieran, Heywood Astra, Huang Zhiyi, Gavryushkin Alex

Abstract excerpt

Large-scale genotype-phenotype screens provide a wealth of data for identifying molecular alterations associated with a phenotype. Epistatic effects play an important role in such association studies. For example, siRNA perturbation screens can be used to identify combinatorial gene-silencing effects. In bacteria, epistasis has practical consequences in determining antimicrobial resistance as the genetic...

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PMID: 36580499
DOI: 10.1371/journal.pcbi.1010730
PMCID: PMC9833600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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