Back to search

Article

Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Lineages

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Intraductal papillary mucinous neoplasms (IPMN) occur in 5-10% of the population, but only a small minority progress to pancreatic ductal adenocarcinoma (PDAC). The lack of accurate predictors of high-risk disease leads both to unnecessary operations for indolent neoplasms as well as missed diagnoses of PDAC. Digital spatial RNA profiling (DSP-RNA) provides an opportunity to de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2357a633-b02e-5f97-a173-7d0a726c0f6b
DOI
10.1101/2024.10.29.620810
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant LineagesDOI 10.1101/2024.10.29.620810
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant StatesSemantic proximity
Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant featuresSemantic proximity
Digital Spatial Profiling of Intraductal Papillary Mucinous Neoplasms: Towards a Molecular Framework for Risk StratificationSemantic proximity
Transcriptomic dissection of Intraepithelial Papillary Mucinous Neoplasms progression by spatial technologies identified novel markers of pancreatic carcinogenesisSemantic proximity
Intraductal Papillary Mucinous Neoplasm Cellular Plasticity is Linked with Repeat Element DysregulationSemantic proximity
Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancerSemantic proximity
Identification of novel spatially resolved markers of malignant transformation in Intraductal Papillary Mucinous NeoplasmsSemantic proximity
Spatial analysis of Intraductal Papillary Mucinous Neoplasms reveals secretory cell-enriched neighborhoodsSemantic proximity
A blood-based signature of cytoskeletal and extracellular remodeling for risk stratification of intraductal papillary mucinous neoplasmsSemantic proximity
Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreasSemantic proximity
Spatial transcriptomics identified mucin-specific O-glycosylation as a key pathway in pancreatic cancer development and a promising therapeutic targetSemantic proximity
Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot ProjectSemantic proximity
Select a neighboring publication to make it the new centre.