Article

Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntington’s disease

2024-07-22

Abstract excerpt

The ordered aggregation of proteins into amyloid fibrils is a hallmark of numerous neurodegenerative diseases. A common strategy in developing therapeutics for amyloid-based diseases relies on preventing or manipulating the aggregation process. However, many amyloid-forming proteins and their aggregates bind and damage organelle and cellular membranes. As such, blocking the ability of these proteins from directly...

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Literature Corpus work: 05910599-9d1a-5c1c-96b1-6f406deede2f
DOI: 10.1101/2024.07.17.603089

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