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Article

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Aug 2012

Sontag Emily Mitchell, Lotz Gregor P, Agrawal Namita, Tran Andrew, Aron Rebecca, Yang Guocheng, Necula Mihaela, Lau Alice, Finkbeiner Steven, Glabe Charles, Marsh J Lawrence, Muchowski Paul J, Thompson Leslie M

Abstract excerpt

Huntington's disease (HD) is a devastating neurodegenerative disorder with no disease-modifying treatments available. The disease is caused by expansion of a CAG trinucleotide repeat and manifests with progressive motor abnormalities, psychiatric symptoms, and cognitive decline. Expression of an expanded polyglutamine repeat within the Huntingtin (Htt) protein impacts numerous cellular processes, including...

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Identifiers

PMID: 22875942
DOI: 10.1523/JNEUROSCI.0895-12.2012
PMCID: PMC3546821

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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