Article

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms

2018-08-08

Abstract excerpt

Amyloids result from the aggregation of several unrelated proteins, due to either specific mutations or promoting intra- or extra-cellular conditions. Structurally, they are rich in intermolecular β-sheets and are the causative agents of several diseases, both neurodegenerative and systemic. It is believed that the most toxic species are small aggregates, referred to as oligomers, rather than the final fibril...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc37f7e8-4b42-5f35-93bb-b80cf321753c
DOI: 10.20944/preprints201808.0155.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Amyloid Aggregation: An Overview of Strategies and MechanismsDOI 10.20944/preprints201808.0155.v1Read

Review: TTR amyloidosis-structural features leading to protein aggregation and their implications on therapeutic strategies.Semantic proximity Read

Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches.Semantic proximity Read

Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds.Semantic proximity Read

Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregationSemantic proximity Read

Hereditary transthyretin amyloidosis: molecular basis and therapeutical strategies.Semantic proximity Read

Amyloids: The History of Toxicity and FunctionalitySemantic proximity Read

Disease-Modifying Treatments for Transthyretin Amyloidosis.Semantic proximity Read

Transthyretin (ATTR) amyloidosis nephropathy: lessons from a TTR stabilizer molecule.Semantic proximity Read

Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments.Semantic proximity Read

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomersSemantic proximity Read

Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione.Semantic proximity Read

Novel drugs targeting transthyretin amyloidosis.Semantic proximity Read