Article
Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.
Proceedings of the National Academy of Sciences of the United States of America - 8 Mar 2022
Song Haikun, Wang Cen, Zhu Chenggang, Wang Ziying, Yang Huiya, Wu Peng, Cui Xiaotian, Botas Juan, Dang Yongjun, Ding Yu, Fei Yiyan, Lu Boxun
Abstract excerpt
Identifying inhibitors of pathogenic proteins is the major strategy of targeted drug discoveries. This strategy meets challenges in targeting neurodegenerative disorders such as Huntington’s disease (HD), which is mainly caused by the mutant huntingtin protein (mHTT), an “undruggable” pathogenic protein with unknown functions. We hypothesized that some of the chemical binders of mHTT may change its conformation...
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