Article

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

2020-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2 orthologs from New World monkey, koala and mouse cannot interact with SARS-CoV-2 to mediate viral entry, and this defect can be restored by humaniz...

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Literature Corpus work: 057c448f-8667-5bfc-abd8-14dadb06292b
DOI: 10.1101/2020.09.20.297242

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