Article

The ancient cardioprotective mechanisms of ACE2 bestow SARS-CoV-2 with a wide host range

2021-01-04

Abstract excerpt

SARS-CoV-2 infects a broader range of mammalian species than previously anticipated, suggesting there may be additional unknown hosts wherein the virus can evolve and potentially circumvent effective vaccines. We find that SARS-CoV-2 gains a wide host range by binding ACE2 sites essential for ACE2 carboxypeptidase activity. Six mutations found only in rodent species immune to SARS-CoV-2 are sufficient to abolish v...

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Literature Corpus work: 22368fba-8f23-5902-b53a-187c09dd3bfd
DOI: 10.1101/2021.01.03.425115

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