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Article

Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication.

mBio - 16 Mar 2021

Adams Lily E, Dinnon Kenneth H, Hou Yixuan J, Sheahan Timothy P, Heise Mark T, Baric Ralph S

Abstract excerpt

The angiotensin-converting enzyme 2 (ACE2) receptor is a major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host range determinant, and understanding SARS-CoV-2-ACE2 interactions will provide important insights into COVID-19 pathogenesis and animal model development. SARS-CoV-2 cannot infect mice due to incompatibility between its receptor binding domain and the murine ACE2 receptor. Through...

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Angiotensin-Converting Enzyme 2
Betacoronavirus
Coronavirus Infections
COVID-19
Host Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

Virus Replication

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Open in PubMed Open full text

Identifiers

PMID: 33727353
DOI: 10.1128/mBio.03149-20
PMCID: PMC8092278

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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