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Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

24 Mar 2021

Abstract excerpt

Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2 orthologs from New World monkey, koala and mouse cannot interact with SARS-CoV-2 to mediate viral entry, and this defect can be restored by humanization of the...

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COVID-19 Clinical Research Studies
COVID-19 epidemiological studies
SARS-CoV-2 and COVID-19 Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33760889
DOI: 10.1371/journal.ppat.1009392

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