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Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2

3 Mar 2021

Abstract excerpt

) are the natural zoonotic reservoir for SARS-CoV-2. However, the host range of SARS-CoV-2 and intermediate hosts that facilitate its transmission to humans remain unknown. The interaction of coronavirus with its host receptor is a key genetic determinant of host range and cross-species transmission. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as the receptor to enter host cells in a species-dependent...

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COVID-19 Clinical Research Studies
SARS-CoV-2 and COVID-19 Research
SARS-CoV-2 detection and testing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33658332
DOI: 10.1073/pnas.2025373118

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