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Article

Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2.

Journal of virology - 17 Jun 2025

Kondo Takashi, Suzuki Rigel, Yajima Hisano, Kawahara Sachiho, Yamaya Kodai, Ichikawa Takaya, Tsujino Shuhei, Suzuki Saori, Tamura Tomokazu, Hashiguchi Takao, Fukuhara Takasuke

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as a receptor to enter host cells, and primary receptor recognition of the spike protein is a major determinant of the host range of SARS-CoV-2. Since the emergence of SARS-CoV-2, a considerable number of variants have emerged. However, the determinants of host tropism of SARS-CoV-2 remain elusive. We...

Topics

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Angiotensin-Converting Enzyme 2
Chlorocebus aethiops
Host Specificity
Receptors, Virus
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 40353671
DOI: 10.1128/jvi.00543-25
PMCID: PMC12172435

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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