Article

Transcriptome-inferred CIN-like fields mark antigen-presentation-low, immune-cold spatial neighborhoods

2026-05-20

Abstract excerpt

Cancer immune escape is usually interpreted as either a tumor-cell-intrinsic antigen-presentation defect or an immune-cold microenvironment. How these states are spatially arranged relative to chromosomal-instability-like genotype states remains unresolved. Here, spatial transcriptomic, single-cell and clinical transcriptomic analyses show that transcriptome-inferred CIN-like fields mark antigen-presentation-low,...

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Literature Corpus work: 05545a91-31e0-5ffc-ab4e-0c4481d9b576
DOI: 10.64898/2026.05.15.725574

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