Article

Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activity

2017-12-05

Abstract excerpt

DNA accessibility is a key dynamic feature of chromatin regulation that can potentiate transcriptional events and tumor progression. Recently, neural networks have begun to make it possible to explore the impact of mutations on DNA accessibility and transcriptional regulation by demonstrating state-of-the-art prediction of chromatin features from DNA sequence data in specific tissue types. We demonstrate enhanceme...

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Literature Corpus work: 1083a50c-7620-5739-9905-ff278d2ac3f1
DOI: 10.1101/229385

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