Article
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma.
Nature communications - 15 Apr 2020
Mitra Akash, Andrews Miles C, Roh Whijae, De Macedo Marianna Petaccia, Hudgens Courtney W, Carapeto Fernando, Singh Shailbala, Reuben Alexandre, Wang Feng, Mao Xizeng, Song Xingzhi, Wani Khalida, Tippen Samantha, Ng Kwok-Shing, Schalck Aislyn, Sakellariou-Thompson Donald A, Chen Eveline, Reddy Sangeetha M, Spencer Christine N, Wiesnoski Diana, Little Latasha D, Gumbs Curtis, Cooper Zachary A, Burton Elizabeth M, Hwu Patrick, Davies Michael A, Zhang Jianhua, Bernatchez Chantale, Navin Nicholas, Sharma Padmanee, Allison James P, Wargo Jennifer A, Yee Cassian, Tetzlaff Michael T, Hwu Wen-Jen, Lazar Alexander J, Futreal P Andrew
Abstract excerpt
Complex tumor microenvironmental (TME) features influence the outcome of cancer immunotherapy (IO). Here we perform immunogenomic analyses on 67 intratumor sub-regions of a PD-1 inhibitor-resistant melanoma tumor and 2 additional metastases arising over 8 years, to characterize TME interactions. We identify spatially distinct evolution of copy number alterations influencing local immune composition. Sub-regions...
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