Article

The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine

2024-12-04

Abstract excerpt

The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria that are acquired from the gut microbiome and/or diet in humans. Following cellular uptake, Q is incorporated at the wobble base (position 34) of tRNAs with a GUN anticodon, which is important for efficient translation. Early studies suggested that cytosolic uptake of queuine is mediated by a selective transporter...

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Literature Corpus work: 0518efe1-ed05-5d8e-a406-d3924532b8ce
DOI: 10.1101/2024.12.03.625470

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