tRNA queuosine modification enzyme modulates the growth and microbiome recruitment to breast tumors

Abstract excerpt

<title>Abstract</title> <p>Background: Transfer RNA (tRNA) queuosine (Q)-modifications occur specifically in 4 cellular tRNAs at the wobble anticodon position. tRNA Q-modification in human cells depends on the gut microbiome because the microbiome product queuine is required for its installation by the enzyme queuine tRNA ribosyltransferase catalytic subunit 1 (QTRT1) encoded in the human genome. Although tRNA Q-...

Topics

Open a Topic to create a Post that cites this publication.

• ATP Synthase and ATPases Research
• Cancer-related gene regulation
• Cardiac Structural Anomalies and Repair
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

123b8482-58be-54f3-a7d4-70deea6702aa

DOI

10.21203/rs.2.21087/v1