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Analysis of queuosine and 2-thio tRNA modifications by high throughput sequencing

17 Jun 2022

Abstract excerpt

Queuosine (Q) is a conserved tRNA modification at the wobble anticodon position of tRNAs that read the codons of amino acids Tyr, His, Asn, and Asp. Q-modification in tRNA plays important roles in the regulation of translation efficiency and fidelity. Queuosine tRNA modification is synthesized de novo in bacteria, whereas in mammals the substrate for Q-modification in tRNA is queuine, the catabolic product of the...

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PMID: 35713550
DOI: 10.1093/nar/gkac517

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