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Article

Queuine ameliorates impaired mitochondrial function caused by mt-tRNAAsn variants.

Journal of translational medicine - 22 Aug 2024

Lin Yan, Wang Jiayin, Zhuang Xingyu, Zhao Ying, Wang Wei, Wang Dongdong, Zhao Yuying, Yan Chuanzhu, Ji Kunqian

Abstract excerpt

BACKGROUND: Mitochondrial tRNA (mt-tRNA) variants have been found to cause disease. Post-transcriptional queuosine (Q) modifications of mt-tRNA can promote efficient mitochondrial mRNA translation. Q modifications of mt-tRNAAsn have recently been identified. Here, the therapeutic effectiveness of queuine was investigated in cells from patients with mt-tRNAAsn variants. METHODS: Six patients (from four families)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39175050
DOI: 10.1186/s12967-024-05574-0
PMCID: PMC11340107

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