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Shank postsynaptic scaffolding proteins in autism spectrum disorder: Mouse models and their dysfunctions in behaviors, synapses, and molecules.

Pharmacological research - 1 Aug 2022

Jung Sunmin, Park Mikyoung

Abstract excerpt

Postsynaptic scaffolding proteins, which are major components of the postsynaptic density (PSD) at excitatory synapses, include Shank, PSD-95, A-kinase anchoring protein, Homer, and SAP90/PSD-95-associated protein families and play crucial roles in synaptic structure, signaling, and functions. Several genetic studies have indicated that postsynaptic scaffolding proteins contribute to the etiology of various...

Topics

Animals
Autism Spectrum Disorder
Disease Models, Animal
Humans
Mice
Mutation
Nerve Tissue Proteins
Synapses

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35792298
DOI: 10.1016/j.phrs.2022.106340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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