Article

UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles in the absence of the motor’s PH domain

2019-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Kinesin-3 KIF1A (UNC-104 in C. elegans ) is the major axonal transporter of synaptic vesicles and mutations in this molecular motor are linked to KIF1A-associated neurological disorders (KAND) including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis and hereditary spastic paraplegia. UNC-104 binds via its PH (pleckstrin homology) domain to the lipid bilayers of membranous vesicles w...

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Literature Corpus work: 0503a0cf-85ea-5552-8a86-057524fa4d3e
DOI: 10.1101/723247

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