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Article

The Caenorhabditis elegans Kinesin-3 motor UNC-104/KIF1A is degraded upon loss of specific binding to cargo.

PLoS genetics - 4 Nov 2010

Kumar Jitendra, Choudhary Bikash C, Metpally Raghu, Zheng Qun, Nonet Michael L, Ramanathan Sowdhamini, Klopfenstein Dieter R, Koushika Sandhya P

Abstract excerpt

UNC-104/KIF1A is a Kinesin-3 motor that transports synaptic vesicles from the cell body towards the synapse by binding to PI(4,5)P(2) through its PH domain. The fate of the motor upon reaching the synapse is not known. We found that wild-type UNC-104 is degraded at synaptic regions through the ub...

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Identifiers

PMID: 21079789
DOI: 10.1371/journal.pgen.1001200
PMCID: PMC2973836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21079789-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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