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A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

2023-07-19

Abstract excerpt

KIF1A, a microtubule-based motor protein responsible for axonal transport, is linked to a group of neurological disorders known as KIF1A-associated neurological disorder (KAND). Current therapeutic options for KAND are limited. Here, we introduced the clinically relevant KIF1A(R11Q) variant into the C. elegans homolog UNC-104, resulting in uncoordinated animal behaviors. Through genetic suppressor screens, we ide...

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Identifiers and source

Literature Corpus work
2f0417fb-f681-51d0-b3a2-f3bfcb9e3303
DOI
10.1101/2023.07.19.548188
Open publication

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A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in NeuronsDOI 10.1101/2023.07.19.548188
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