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Article

A plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2024

Chai Yongping, Li Dong, Gong Weibin, Ke Jingyi, Tian Dianzhe, Chen Zhe, Guo Angel, Guo Zhengyang, Li Wei, Feng Wei, Ou Guangshuo

Abstract excerpt

KIF1A, a microtubule-based motor protein responsible for axonal transport, is linked to a group of neurological disorders known as KIF1A-associated neurological disorder (KAND). Current therapeutic options for KAND are limited. Here, we introduced the clinically relevant KIF1A(R11Q) variant into the Caenorhabditis elegans homolog UNC-104, resulting in uncoordinated animal behaviors. Through genetic suppressor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38271337
DOI: 10.1073/pnas.2311936121
PMCID: PMC10835061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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