Article

JIP3 regulates bi-directional organelle transport in neurons through its interaction with dynein and kinesin-1

2021-10-11

Abstract excerpt

<h4>SUMMARY</h4> The conserved MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons of vertebrates and invertebrates. Whether and how JIP3’s interaction with dynein and kinesin-1 contributes to this critical organelle clearance function is unclear. Using purified recombinant human proteins, we show that dynein light intermediate chain (DLIC) binds to the N-terminal RH1 domain of JIP3,...

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Literature Corpus work: 2b065f95-780d-5643-9c1b-afbd894f19aa
DOI: 10.1101/2021.10.11.463801

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