Article

Characterizing Human KIF1Bß Motor Activity by Single-Molecule Motility Assays and <i>Caenorhabtidis elegans</i> Genetics

2023-11-13

Abstract excerpt

The axonal transport of synaptic vesicle precursors relies on KIF1A and UNC-104 ortholog motors. In mammals, KIF1Bß is also responsible for the axonal transport of synaptic vesicle precursors. Mutations in KIF1A and KIF1Bß lead to a wide range of neuropathies. While previous studies have revealed the biochemical, biophysical and cell biological properties of KIF1A, and its defects in neurological disorders, the fu...

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Literature Corpus work: e89df629-9bb5-5a24-8c71-d44ccbfd3f03
DOI: 10.1101/2023.11.12.566784

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