SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension

Abstract excerpt

<title>Abstract</title> <p>Emerging evidence indicates that endothelial cell senescence plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanisms and signaling pathways driving pulmonary endothelial senescence in PAH remain incompletely understood. In this study, we used a novel functional genomics approach to show that the intermediate filament protein...

Topics

Open a Topic to create a Post that cites this publication.

• Exome Sequencing
• Familial Primary Pulmonary Hypertension
• Genetic Predisposition to Disease
• Heart Ventricles
• Pulmonary Arterial Hypertension
• Pulmonary Hypertension Research and Treatments
• SOXF Transcription Factors
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

04ff9746-c819-5f06-959d-6f1c407bee83

DOI

10.21203/rs.3.rs-6999919/v1