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Epigenetic CRISPR Screening of 9p21.3 Non-Coding Regions identifies Cis-Regulatory Elements of P16 <sup>INK4a</sup> and P15 <sup>INK4b</sup> Controlling Cellular Senescence

2025-09-30

Abstract excerpt

Cellular senescence is a hallmark of aging and a promising target for extending human healthspan. Senescence is often accompanied by upregulation of the key senescence marker gene CDKN2A , yet the mechanism underlying its transcriptional activation remains unclear due to complex cis -regulations within the 9p21.3 locus. Here, we performed complementary CRISPR activation and interference screens in human mesenchy...

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Literature Corpus work
30c9fd1d-103f-5423-96b6-e2682745fa82
DOI
10.1101/2025.09.29.679215
Open publication

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Epigenetic CRISPR Screening of 9p21.3 Non-Coding Regions identifies Cis-Regulatory Elements of P16 <sup>INK4a</sup> and P15 <sup>INK4b</sup> Controlling Cellular SenescenceDOI 10.1101/2025.09.29.679215
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